@import url('https://fonts.googleapis.com/css2?family=DM+Sans:wght@400;500;600;700&family=Manrope:wght@400;500;600;700;800&display=swap');
:root{--ink:#17263e;--muted:#58667a;--line:#dbe2ec;--paper:#f3f6fb;--blue:#1467dd;--patent:#854cce;--preprint:#ca611b;--activity:#00897b;--none:#cbd3df;--excluded:#e6e9ee}*{box-sizing:border-box}body{margin:0;background:var(--paper);color:var(--ink);font-family:'DM Sans',sans-serif;font-size:16px}button,input,select{font:inherit}button,a,input,select,summary{touch-action:manipulation}button{cursor:pointer}a{color:var(--blue)}button:focus-visible,a:focus-visible,input:focus-visible,select:focus-visible,summary:focus-visible{outline:3px solid #ec9b17;outline-offset:3px}header{min-height:78px;background:#fff;border-bottom:1px solid var(--line);display:flex;align-items:center;justify-content:space-between;padding:16px 4%;gap:18px}.brand{display:flex;align-items:center;gap:12px;letter-spacing:1.8px;font-size:14px;font-weight:800;color:var(--ink);text-decoration:none}.brand-mark{background:var(--ink);color:#fff;border-radius:6px;padding:8px;letter-spacing:-1px;font-size:18px}.edition{font-size:12px;letter-spacing:1.4px;color:var(--muted)}.edition span{padding:0 9px}main{max-width:1600px;margin:auto;padding:32px 4%}.intro{display:grid;grid-template-columns:1.1fr 1fr;gap:40px;padding:8px 0 32px;align-items:center}.eyebrow{font-size:12px;font-weight:700;letter-spacing:1.6px;color:var(--blue);margin:0 0 12px}h1{font-family:Manrope,sans-serif;font-size:clamp(30px,3vw,45px);line-height:1.15;letter-spacing:-1.6px;margin:0 0 14px;font-weight:800}h1 em{font-style:normal;color:var(--blue)}.intro p:not(.eyebrow){max-width:600px;color:var(--muted);line-height:1.6;margin:0}.numbers{background:var(--ink);color:white;border-radius:14px;padding:25px 28px}.ratio{display:flex;align-items:baseline;gap:10px}.ratio strong{font-family:Manrope,sans-serif;font-size:56px;letter-spacing:-2px;font-weight:800;color:#87bbff}.ratio span{font-size:16px;color:#d7e5fa}.numbers p{color:#d7e5fa!important;font-size:14px}.ratio-bar{display:flex;height:9px;border-radius:10px;overflow:hidden;background:#4c5d73;margin:18px 0}.ratio-bar i{min-width:2px}.stat-breakdown{display:flex;flex-wrap:wrap;gap:14px;font-size:13px;color:#d7e5fa}.stat-breakdown b{color:white}.toolbar{display:flex;gap:16px;padding:18px 20px;border-bottom:1px solid var(--line);align-items:center;background:#fff;border-radius:12px 12px 0 0}.workspace{border:1px solid var(--line);background:white;border-radius:12px;overflow:hidden;box-shadow:0 8px 30px #24355005}.search{display:flex;align-items:center;gap:10px;background:var(--paper);border:1px solid var(--line);border-radius:7px;padding:10px 12px;flex:1}.search span{font-size:26px;line-height:20px}.search input{border:0;outline:none;background:none;width:100%;min-width:0;color:var(--ink)}.class-select{display:flex;gap:8px;align-items:center;font-size:14px;color:var(--muted)}select{border:1px solid var(--line);border-radius:6px;padding:10px;background:white;color:var(--ink);max-width:220px}.quiet{border:1px solid var(--line);background:white;border-radius:6px;padding:9px 12px;font-size:14px;color:var(--ink)}.quiet:hover{background:var(--paper)}.workspace-grid{display:grid;grid-template-columns:minmax(0,1.65fr) minmax(300px,1fr)}.landscape{padding:24px;border-right:1px solid var(--line);min-width:0}.section-head{display:flex;align-items:start;justify-content:space-between;gap:12px}.section-head h2{font-family:Manrope,sans-serif;font-size:19px;margin:0 0 5px;letter-spacing:-.4px}.section-head p{font-size:14px;color:var(--muted);margin:0}.section-head .quiet{font-size:12px;max-width:155px}.legend{display:flex;gap:12px;flex-wrap:wrap;margin:19px 0 10px;font-size:12px;color:var(--muted)}.legend span{display:flex;align-items:center;gap:6px}.dot{display:inline-block;width:9px;height:9px;background:var(--none);border-radius:50%;flex:none}.published{background:var(--blue)}.patent{background:var(--patent)}.preprint{background:var(--preprint)}.activity{background:var(--activity)}.excluded{background:var(--excluded);border:1px solid #abb3c0}.map-note{font-size:13px;line-height:1.5;color:var(--muted);border-left:2px solid #bdcee5;padding-left:10px;margin:12px 0 20px}#map{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:12px;align-items:start}.family{background:#f8faff;border:1px solid #e6ebf2;border-radius:7px;padding:12px;min-width:0}.family.large{grid-column:1/-1}.family-head{display:flex;gap:8px;justify-content:space-between;align-items:start;margin-bottom:10px}.family-title{font-size:14px;font-weight:700;border:0;padding:0;background:none;color:var(--ink);text-align:left}.family-head span{font-size:12px;white-space:nowrap;color:var(--muted)}.marks{display:grid;grid-template-columns:repeat(auto-fill,minmax(12px,1fr));gap:3px}.mark{width:100%;aspect-ratio:1;max-width:15px;min-height:10px;padding:0;border:0;border-radius:50%;background:var(--none);position:relative}.mark.published{background:var(--blue)}.mark.patent{background:var(--patent)}.mark.preprint{background:var(--preprint)}.mark.activity{background:var(--activity)}.mark.excluded{background:#e8ebf0;border:1px solid #cbd3df}.mark.match{outline:2px solid #111f33;outline-offset:2px;z-index:1}.mark.dim{opacity:.18}.mark:hover{transform:scale(1.5);outline:2px solid #17263e;z-index:2}.family-tags{display:flex;gap:5px;flex-wrap:wrap;margin-top:10px}.gene-tag{border:1px solid #c4d9f7;background:#eaf2ff;color:#164f9b;font-size:12px;border-radius:4px;padding:4px 6px;font-weight:700}.gene-tag.patent-tag{color:#6e3dae;background:#f4edff;border-color:#dfcdf5}.gene-tag.preprint-tag{color:#924315;background:#fff1e9;border-color:#f2d3bb}.gene-tag.activity-tag{color:#00695c;background:#e8f7f4;border-color:#bde1da}.caption{font-size:13px;color:var(--muted);line-height:1.5}.finder{padding:24px;min-width:0;background:#fff}.filters{display:flex;gap:5px;margin:18px 0 12px;background:var(--paper);padding:4px;border-radius:7px}.filters button{border:0;background:none;padding:9px 6px;border-radius:5px;font-size:13px;color:var(--muted);flex:1}.filters button[aria-pressed=true]{background:white;color:var(--ink);box-shadow:0 1px 5px #142c4820;font-weight:700}.results{max-height:790px;overflow:auto;padding-right:4px}.target-card{display:block;width:100%;background:white;border:1px solid var(--line);border-radius:8px;padding:14px;text-align:left;margin:10px 0;color:var(--ink);transition:border-color .15s}.target-card:hover{border-color:var(--blue);background:#f9fbff}.target-top{display:flex;justify-content:space-between;align-items:center;gap:7px;margin-bottom:7px}.target-top strong{font-size:18px;font-family:Manrope,sans-serif}.badge{font-size:12px;padding:3px 6px;background:#eaf2ff;color:#164f9b;border-radius:4px}.badge.patent-badge{color:#6e3dae;background:#f4edff}.badge.preprint-badge{color:#924315;background:#fff1e9}.badge.activity-badge{color:#00695c;background:#e8f7f4}.badge.none-badge,.badge.excluded-badge{background:#eef1f5;color:var(--muted)}.target-meta{font-size:13px;color:var(--muted)}.target-measure{font-size:14px;margin:8px 0 0;line-height:1.5}.target-measure b{color:var(--blue)}.empty{padding:25px 10px;color:var(--muted);line-height:1.6}.methodology{margin-top:24px;border:1px solid var(--line);border-radius:8px;background:white;padding:18px 22px}summary{cursor:pointer;font-weight:700}.method-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:30px;margin:20px 0 5px}.method-grid h3{font-size:16px}.method-grid p{font-size:14px;line-height:1.65;color:var(--muted)}.method-grid a,.text-button{font-size:14px}.text-button{background:none;border:0;color:var(--blue);padding:10px 0;display:block}footer{display:flex;justify-content:space-between;gap:20px;font-size:12px;color:var(--muted);padding:26px 0;line-height:1.5}footer span:first-child{letter-spacing:1px;font-weight:700}dialog{border:1px solid var(--line);border-radius:14px;padding:32px;max-width:640px;width:calc(100% - 30px);max-height:88vh;color:var(--ink);box-shadow:0 20px 80px #08192b44}dialog::backdrop{background:#14243c77;backdrop-filter:blur(3px)}.close{position:absolute;right:16px;top:12px;background:none;border:0;font-size:30px;color:var(--muted)}dialog h2{font-family:Manrope,sans-serif;font-size:32px;margin:15px 0 5px}dialog h3{font-size:18px;margin:0 0 12px}.detail-sub{color:var(--muted);font-size:14px;line-height:1.6}.evidence{border-top:1px solid var(--line);padding:20px 0 10px;margin-top:18px}.evidence .value{font-size:24px;font-weight:700;letter-spacing:-.5px;margin:10px 0}.evidence p{font-size:15px;line-height:1.6}.evidence a{font-size:14px}.detail-notice{background:#f1f5fc;padding:12px;border-radius:6px;font-size:14px;line-height:1.6}.warn{color:#8c4b14}.show-more{width:100%;margin:10px 0}#loadError{padding:30px;background:#fff0e9;color:#8f3c10}body:has(dialog[open]){overflow:hidden}@media(min-width:1400px){.marks{grid-template-columns:repeat(auto-fill,minmax(13px,1fr))}}@media(max-width:1050px){.edition{display:none}.workspace-grid{grid-template-columns:minmax(0,1.2fr) minmax(290px,1fr)}.landscape,.finder{padding:18px}.intro{gap:24px}#map{grid-template-columns:1fr}.family.large{grid-column:auto}}@media(max-width:760px){header{padding:12px 5%}.intro{grid-template-columns:1fr;gap:22px}.numbers{padding:20px}.ratio strong{font-size:44px}.intro h1 br{display:none}.workspace-grid{display:flex;flex-direction:column}.finder{order:-1;border-bottom:1px solid var(--line)}.results{max-height:365px}.landscape{border-right:0}.toolbar{flex-wrap:wrap;padding:14px;gap:10px}.search{flex-basis:100%}.class-select{flex:1}select{flex:1;max-width:100%;min-width:0}.method-grid{grid-template-columns:1fr;gap:4px}main{padding:24px 4%}footer{flex-direction:column;gap:8px}.mark{min-height:12px}.section-head h2{font-size:18px}}@media(prefers-reduced-motion:reduce){*{transition:none!important}}

.skip{position:absolute;top:-100px;left:20px;background:white;padding:12px;z-index:20}.skip:focus{top:10px}

.class-coverage{margin-top:22px;padding-top:18px;border-top:1px solid #4c5d73}.class-coverage .ratio{align-items:center}.class-coverage .ratio strong{font-size:44px}.class-coverage .ratio span{max-width:260px;line-height:1.4;font-weight:700}.class-coverage p{font-size:12px;margin-top:6px!important}.class-links{display:flex;flex-wrap:wrap;gap:6px;margin-top:12px}.class-links button{color:#e3eeff;background:#253c5b;border:1px solid #547095;border-radius:5px;padding:5px 8px;font-size:12px}.class-links button:hover{background:#365477}

.automation-notice{padding:16px 20px;border:1px solid #edcf9c;border-left:4px solid #b76712;background:#fff8eb;border-radius:8px;margin-bottom:18px;font-size:14px;line-height:1.6}.automation-notice p{margin:5px 0}.automation-notice span{color:var(--muted);font-size:13px}.recent-strip{display:flex;justify-content:space-between;align-items:center;gap:16px;padding:18px 20px;background:#e9f2ff;border:1px solid #bfd5f3;border-radius:8px;margin-bottom:18px}.recent-strip h2{font-size:18px;margin:0 0 6px}.recent-strip p{font-size:14px;margin:0;color:var(--muted);line-height:1.5}.first-report{font-size:14px;font-weight:700;margin-top:9px;color:#265c8c}.new-badge{display:inline-block;font:700 12px 'DM Sans',sans-serif;color:#00655a;background:#d5f3ed;padding:3px 5px;border-radius:4px;margin-left:7px;vertical-align:middle}.history{background:#edf4ff;padding:12px;border-radius:6px;margin:14px 0;font-size:14px;line-height:1.6}.history p{margin:5px 0 0;color:var(--muted)}@media(max-width:760px){.recent-strip{align-items:start;flex-direction:column}.recent-strip button{width:100%}}

.toolbar{flex-wrap:wrap}.toolbar .search{min-width:240px}#scopeToggle{white-space:nowrap}

.timeline-section{margin:24px 0;background:white;border:1px solid var(--line);border-radius:14px;padding:22px}.timeline-scroll{overflow-x:auto;padding:8px 0 16px}.timeline-scroll:focus-visible{outline:3px solid #ec9b17}#timeline{display:flex;width:max-content;min-width:100%;align-items:stretch}.timeline-year{width:82px;flex-shrink:0;border-top:3px solid #b5c7df;position:relative;padding:10px 5px;min-height:110px}.timeline-year.decade{border-left:1px solid var(--line)}.year-label{font-size:14px;color:var(--muted);margin-bottom:12px}.has-events .year-label,.decade .year-label{font-weight:700;color:var(--ink)}.year-events{display:flex;flex-direction:column;gap:6px}.timeline-gene{border:0;border-radius:5px;padding:6px 3px;font-size:13px;font-weight:700;cursor:pointer}.clinical-badge{font-size:13px;padding:5px 8px;border-radius:5px;margin:8px 0;background:#eef2f7;color:#4d5b70}.clinical-approved{background:#deefe6;color:#16513b}.clinical-clinical{background:#e2edff;color:#174d92}.clinical-historical,.clinical-secondary{background:#fff0d8;color:#755018}.clinical-detail{border:1px solid var(--line);border-radius:8px;padding:16px;margin:18px 0}.clinical-detail h4{margin-bottom:6px}.clinical-detail article+article{border-top:1px solid var(--line);padding-top:12px}.clinical-detail a{overflow-wrap:anywhere}.class-select{max-width:100%}.class-select select{max-width:300px}

.scope-control{display:flex;align-items:center;justify-content:space-between;gap:20px;padding:20px 24px;margin-bottom:22px;border:2px solid var(--blue);border-radius:12px;background:#e9f2ff}.scope-control strong{font-size:18px}.scope-control p{margin:6px 0 0;font-size:14px;line-height:1.5;color:var(--muted)}.scope-toggle{display:flex;align-items:center;gap:12px;min-height:52px;padding:12px 18px;border:2px solid var(--blue);border-radius:8px;background:#fff;color:#124f9f;font-weight:700;font-size:16px}.scope-toggle::before{content:"";flex:none;width:42px;height:24px;border-radius:20px;background:radial-gradient(circle at 12px 12px,#fff 8px,transparent 9px),#64748b}.scope-toggle[aria-pressed=true]{background:var(--blue);color:#fff}.scope-toggle[aria-pressed=true]::before{background:radial-gradient(circle at 30px 12px,#fff 8px,transparent 9px),#084392}.scope-toggle:hover{box-shadow:0 0 0 3px #1467dd25}.methodology+.automation-notice{margin-top:20px}@media(max-width:760px){.scope-control{align-items:stretch;flex-direction:column;padding:18px}.scope-toggle{justify-content:center}#scopeToggle{white-space:normal}}

.disease-controls{padding:22px 20px;border-bottom:1px solid var(--line);margin:0}.disease-controls h3{margin:0 0 8px}.disease-controls p{font-size:14px;line-height:1.5;margin:8px 0 0}.disease-inputs{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:14px;margin:18px 0}.disease-inputs label{display:flex;flex-direction:column;gap:8px;font-size:14px}.disease-inputs select,.disease-inputs input{font:inherit;padding:11px;border:1px solid #bac9d5;border-radius:6px;background:#fff;color:#142f41;min-width:0;width:100%;max-width:none}.disease-badge{font-size:14px;color:#315b70;margin:9px 0;line-height:1.45}.disease-detail{border-top:1px solid #ccd7e0;margin-top:22px;padding-top:12px}.disease-record{border-top:1px solid #dbe3e9;padding:12px 0}.disease-record h4{margin:0 0 6px}.disease-record p{margin:6px 0;overflow-wrap:anywhere}.source-versions{margin-top:18px}.disease-detail summary{cursor:pointer;font-size:14px;padding:10px 0}@media(max-width:800px){.disease-inputs{grid-template-columns:1fr}}

@media(max-width:760px){.disease-controls{padding:18px 14px}}